Sunday, March 31, 2013

Egypt issues arrest warrant for TV satirist

CAIRO (AP) ? Egypt's state prosecutors ordered the arrest Saturday of a popular television satirist for allegedly insulting Islam and the country's leader, in a move that government opponents say is aimed at silencing critics of Islamist President Mohammed Morsi.

The arrest warrant for against Bassem Youssef, who has come to be known as Egypt's Jon Stewart, followed an order earlier this week by the country's top prosecutor to arrest five prominent pro-democracy activists in what the opposition has characterized as a widening campaign against dissent.

The acceleration in legal action targeting protesters, activists and critics comes against a backdrop of continued unrest in the country. Political compromise between the well-organized Islamists in power and their vocal liberal and largely secular critics remains elusive, while the country's economy is in near free fall, which has increasingly fueled popular frustration.

The opposition charges that Morsi, in office for nine months, and the Brotherhood have failed to tackle any of the nation's most pressing problems and are trying to monopolize power, breaking their promises of inclusiveness. Morsi blames the country's woes on nearly three decades of corruption under his predecessor, Hosni Mubarak, and accuses the opposition of stoking unrest for political gain.

The warrant against Youssef is the latest in a series of legal actions against the comedian, whose widely-watched weekly show, "ElBernameg" or "The Program," has become a platform for lampooning the government, opposition, media and clerics. He has also used his program to fact-check politicians.

The fast-paced show has attracted a wide viewership, while at the same time earning itself its fair share of detractors. Youssef has been a frequent target of lawsuits, most of them brought by Islamist lawyers who have accused him of "corrupting morals" or violating "religious principles."

Prosecutor Mohammed el-Sayed Khalifa told Al-Ahram online that he has heard 28 plaintiffs accusing Youssef of insulting Islam, mocking prayers, and "belittling" Morsi in the eyes of the world and his own people.

In one episode of the show, Youssef mocks former militants who are now part of the mainstream political scene in Egypt. At a recent rally, some former radicals who were imprisoned for taking part in the assassination of late President Anwar Sadat in 1981, accused the opposition of using violence at anti-Morsi protests.

In the program, Youssef ridicules an Islamist who said the militants had repented by fasting for three months for mistakenly killing others with Sadat.

"What a message," Youssef says. "Anyone can form a group in the name of religion, assassinate in the name of religion, and then oops! Repent and fast for three months, and it will too pass in the name of religion."

The comedian has faced several court cases in the past accusing him of insulting Morsi. One of Youssef's attorneys, Gamal Eid, said however that this is the first time an arrest warrant has been issued for the comedian.

In a post on his official Twitter account, Youssef said he will hand himself in to the prosecutor's office Sunday. He then added, with his typical sarcasm: "Unless they kindly send a police van today and save me the transportation hassle."

Eid said the warrant fits into a widening campaign against government critics, media personalities, and activists, saying "the prosecution has become a tool to go after the regime's opposition and intimidate it."

A call to a top aide to the country's chief prosecutor, Hassan Yassin, for comment went unanswered.

The other recent arrest warrants for five high-profile activists were issued over allegations that they instigated violence last week near the Brotherhood's headquarters in Cairo, where nearly 200 people were injured in clashes between anti-government protesters and supporters of the Brotherhood, from which Morsi hails.

Morsi responded by harshly criticizing his opponents, calling them hired thugs out to derail Egypt's democracy. The Brotherhood also blamed privately-owned media for fanning the violence.

The criticism was followed by a two-day protest by dozens of Islamists outside the studios of TV networks critical of Morsi. The protesters pelted police and prevented some talk show hosts and guests from entering or leaving the complex.

The New York-based Committee to Protect Journalists called the escalation of anti-press "rhetoric" by Morsi and his supporters and the sit-in outside the media city were "deeply troubling."

The series of prosecutions and arrest warrants come amid a legal challenge to the chief prosecutor, Talaat Abdullah, whose appointment by Morsi last year was declared void by a court ruling earlier this week.

On Saturday, Abdullah said he will appeal the court ruling, saying it is "in violation of the constitution and the law," Egypt's state news agency reported. The decision signals a protracted legal battle is likely to ensue, further confusing the legal scene in Egypt.

In the Mediterranean port city of Alexandria, an Egyptian rights group said Saturday that police detained 13 people, including five lawyers, and accused them of assaulting police. The arrests inside the police station mark a rare instance in which lawyers face potential criminal charges.

The Haqanya Center for Rights said the 13 are accused of insulting security officials, attempting to free other detainees at the police station and illegal assembly.

The arrests prompted an angry response from lawyers at Cairo's Bar Association, who demanded an apology from the police.

Those detained include prominent lawyer and pro-democracy activist Mahienour el-Masry. Several dozen Cairo protesters held a rally outside the chief prosecutor's office, dismissing his orders as void, locking up the gates to his office with chains and demanding the release of the lawyers and activists.

Mohammed Abdel-Aziz, an attorney, said the lawyers and activists were beaten and assaulted at the station, where they had been since Friday to represent three opposition members reportedly detained and taken to the police by members of a political party affiliated with the Brotherhood.

Source: http://news.yahoo.com/egypt-issues-arrest-warrant-tv-satirist-132500262.html

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Women Wrestlers Hit the Mat for Breast Cancer | KTXL FOX40

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Source: http://fox40.com/2013/03/29/women-wrestlers-hit-the-mat-for-breast-cancer/

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Saturday, March 30, 2013

Abrakadoodle Art Education Opens First Unit in ... - Franchising.com

Children's art and creativity programs set to get underway in Northwest Arkansas this spring.

March 29, 2013 // Franchising.com // Reston, VA - Abrakadoodle Remarkable Art Education is expanding its reach to children with the addition of its first franchise unit in Arkansas. The mother/daughter duo Cora J. and Joy Davis of Fayetteville will be providing a wide range of art programs to include visual arts classes, camps, workshops, as well as in-school field trips, special events and arty parties at schools, community centers, faith-based locations and other sites that serve children throughout Northwest Arkansas to include Bentonville, Fayetteville, Rogers and Springdale.

"We are delighted to welcome Joy and Cora to our award-winning Abrakadoodle franchise system," said Rosemarie Hartnett, CFE, President and Co-Founder of Abrakadoodle, Inc. "They bring impressive educational backgrounds and a true passion for education and creative literacy, which I am confident will help ensure their tremendous success in a community that values art, culture and creativity."

"Creative literacy is very important for children," stated Cora J. Davis, Director of Abrakadoodle-Northwest Arkansas. "Abrakadoodle will provide an educationally-rich learning environment enabling children to develop skills and imagination." Married to Paul, mother of three (Kendrick, Vanessa and Joy) and grandmother of two young children (Kennedy and Katelynn), Cora brings to Abrakadoodle 15 years of K-5 teaching experience, as well as a BS in Elementary Education, a Master's in Education, and she is working on her PhD in Public Policy and Education at the University of Arkansas-Fayetteville. She explained that her daughter Joy approached her about the opportunity to operate a well-respected art education franchise, an idea she met with enthusiasm.

""I always dreamed of owning my own business," Joy Davis, Director of Abrakadoodle-Northwest Arkansas remarked. Joy discovered Abrakadoodle when she read a business magazine and saw a fit with Abrakadoodle's creative concept. From a long line of educators, Joy brings a BS in Biology and a Master's in Operations Management. "Through Abrakadoodle, we will stimulate creativity in children, which they will carry with them throughout their lives. I find that very exciting!"

To learn more about art programs or to bring Abrakadoodle classes and activities to your location, please go to www.abrakadoodle.com/AR01/ or contact Joy Davis at jdavis@abrakadoodle.com or 479-856-6651.

Abrakadoodle was the first American franchise company to bring a comprehensive, standards-based art education program to children in the U.S. More than just a drawing program, Abrakadoodle embraces art in its broadest scope - from public art to all types of painting, sculpture, animation, paper and fabric art, digital photography and more. Abrakadoodle students develop a fine arts vocabulary as they learn about the styles and techniques of such artists as Michelangelo, Monet, Picasso, Ansel Adams, as well as contemporary artists through its Artist of Distinction program. Abrakadoodle students use an abundance of creative materials (bamboo brushes, sculpting materials, fabric, watercolor, acrylics, and more) to explore the visual arts. Students often take home framed, labeled original creations that extend the learning at home, as well as boost self-confidence.

Abrakadoodle classes employ a "process art" methodology. These classes not only inspire a child's imagination, but they also build motor, language and cognitive skills. Abrakadoodle students develop an appreciation for art and a sense of craftsmanship. Research suggests that getting an early start in the arts can make a real difference in the lives of children, not only in terms of increased academic achievement but also greater problem solving, leadership capabilities, and confidence.

About Abrakadoodle

Abrakadoodle was co-founded in 2002 by award-winning educator/franchise developer Mary Rogers, CFE, MA.Ed, and children's services franchising expert Rosemarie Hartnett, CFE. Abrakadoodle is the most comprehensive creativity and art education company of its kind, offering extensive visual arts classes, camps and parties for children ages 20 months to 12 years old. Abrakadoodle has received seven First Place Awards from Nickelodeon's Parent Picks Awards for "Best Art Program to inspire your child's inner Picasso." Recently Abrakadoodle also received seven additional nominations for "Best Kids Party Entertainer" and "Best Kids Party Place."

SOURCE?Abrakadoodle

Contact:

Joy Davis
Director
479-856-6651
jdavis@abrakadoodle.com

Karin Machusic
Director of Public Relations
(Mobile) 925-708-2179
Karin@abrakadoodle.com

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Source: http://www.franchising.com/news/20130329_abrakadoodle_art_education_opens_first_unit_in_ark.html

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Slovenia will not be the next Cyprus: finance minister

By Marja Novak and Zoran Radosavljevic

LJUBLJANA (Reuters) - Slovenia will not be the next euro member to need a financial rescue as it can afford to wait for lower borrowing costs before issuing new debt, its top economic official said on Friday.

The new center-left government was widely expected to raise money on financial markets shortly after taking office on March 20 but has not done so because Slovenia's borrowing costs have soared due to the turmoil in Cyprus.

Investors are betting that Slovenia, another tiny member of Europe's currency zone with a population of just 2 million, will also need a rescue to keep its banks and economy afloat.

Last week, Cyprus became the fifth euro member to receive financial help from Brussels to survive a regional debt crisis.

While Slovenia's banks are also in trouble the sector is smaller than in Cyprus and it does not share the exposure to toxic Greek debt and Finance Minister Uros Cufer said his country did not need help.

"We will need no bailout this year," he said. "I am calm."

Like many other euro zone members, Slovenia is in recession, with slowing exports to its neighbors and high unemployment.

It last issued a bond in October last year before the conservative government collapsed over a corruption scandal in January and was this month replaced by the new center-left cabinet of Prime Minister Alenka Bratusek.

Analysts were expecting a swift debt issue from the government but yields have jumped. The 2021 bond yield rose to 6.06 percent on Friday, from 5.45 a week ago.

The International Monetary Fund says Slovenia will need to raise at least 3 billion euros this year for the budget, debt repayment and the bank overhaul, and former Prime Minister Janez Jansa has said Slovenia must issue debt by June.

But Cufer said Slovenia, a mountainous country on the Adriatic neighbored by Austria, Italy, Croatia and Hungary, was not in a hurry.

"We do not have to go to the markets in these overheated times due to Cyprus," he said. "We can wait for the markets to calm down, for the investors to feel comfortable about our action and then we will tap the market."

BAD BANK

He said the government would launch a "bad bank" by September that would take over a part of 7 billion euros in bad loans from the three main banks, all of which are in majority or large state ownership.

The banks would then require up to 1 billion euro ($1.28 billion) in a capital injection, which Cufer said Slovenia could raise later this year via a bond, part of the total 3 billion in planned debt issuance for this year.

With successive governments citing national interests, Slovenia was the only ex-communist state that refused to sell its largest lenders ahead of EU entry last decade, creating a toxic combination of political control and poor management in banks that backfired when the economy went downhill in 2009.

The global financial crisis ended years of fast growth and indiscriminate lending that included loans worth a reported 187 million euros from one bank to the largest builder, SCT, which went bankrupt after a collapse in real estate and construction.

Many other highly leveraged local companies went bust, sticking banks with more bad loans that combined amount to about a fifth of the economy.

Cufer, 42, took part in shaping the bad bank under a plan launched by the previous conservative government on the side of the biggest lender, Nova Ljubljanska Banka (NLB), where he worked as head of financial management.

He said the bad bank had already been established and would be fully operational "surely in a few months, definitely by the start of September".

Along with the 1 billion euros to shore up their balance sheets this year, the lenders will swap bad loans in exchange for state-guaranteed bonds issued by the bad bank, he said.

NO BANK SALES SOON

Cufer said the banks were now worth 10-20 percent of their book value, which would be 25 to 50 million euros, and the government would wait until they were recapitalized and markets stabilized before sells them into private hands.

"Now is not the appropriate time to sell. Selling at these prices makes no sense... Even next year is very optimistic," he said.

Cufer tried to stress that unlike Cyprus - where banking assets were seven times larger than the economy, as opposed to about 1.3 times for Slovenia - Ljubjana could handle its problems on its own.

"Slovenia cannot be compared to Cyprus, it is certainly not a tax haven... the basic problem of the banks in Slovenia is too much debt in companies and a lack of capital," he said.

To offset the costs of bank cleanup, the government will step up the sale of state companies rather than pursue the type of austerity measures that have deepened economic downturns in Greece, Portugal and other struggling states.

He declined to name what companies could be privatized but said they would continue with the program of the previous government. He added there would be at least "one major privatization" by the end of the year.

The last government was mulling selling stakes in telecoms operator Telekom Slovenia, insurer Zavarovalnica Triglav and fuel retailer Petrol. ($1 = 0.7788 euros)

(Writing by Zoran Radosavljevic; editing by Michael Winfrey and Anna Willard)

Source: http://news.yahoo.com/slovenia-not-next-cyprus-finance-minister-012924950.html

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If 'Girls,' 'Full House' And More Had 'Game Of Thrones' Sigils

HBO has released a delightful sigil-maker before the start of the third season of Game of Thrones. This got me thinking, what would some of the most famous characters from fiction adopt as their sigils and mottos if they were in the world of Westeros? Let's have a look.

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Source: http://www.huffingtonpost.com/2013/03/29/game-of-thrones-sigils_n_2980146.html

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Friday, March 29, 2013

This is the Modem World: Nerds in rabbit holes

Each week Joshua Fruhlinger contributes This is the Modem World, a column dedicated to exploring the culture of consumer technology.

DNP This is the Modem World Nerds in Rabbit Holes

I have many interests: mountain biking, martial arts, video games, running, reading, cooking and horror movies. For each one of these, there is an internet rabbit hole so deep, so full of information and compatriots that it's a miracle I ever actually follow through on them. Ask yourself this: Do you do what you say you do online?

The internet is great at allowing people to nerd out on their particular interests. While it serves up news and media like a champ, many of us spend our time deep-diving into whatever rabbit hole interests us. When we nerd out about technology here at Engadget, for instance, we're getting a double dose: reading about technology in a tech environment. It's a beautiful thing; it's addictive and we lose sight of reality while we're going deep. We could be in a bar, at home, at the office -- wherever it is, we lose sense of our environment.

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Source: http://www.engadget.com/2013/03/27/nerds-in-rabbit-holes/

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Report: Rep. Gohmert 'rude and irate' after ticket

WASHINGTON (AP) ? A Texas congressman was "rude and irate" after receiving a parking ticket near the Lincoln Memorial earlier this month, according to a police report.

Rep. Louie Gohmert, R-Texas, told U.S. Park Police he was on a committee that oversees the agency and would not pay a fine, according to the report, which was obtained by Politico. Gohmert was given a citation after 11 p.m. on March 13 for parking his vehicle in a spot reserved for National Park Service vehicles.

The outspoken conservative lawmaker referred officers to a congressional plate in his car window, according to the police report, and left without the ticket.

Kimberly Willingham, a spokeswoman for Gohmert, said the congressman parked in a one of several empty spots and believed he was allowed to do so. She said a park service officer apologized to Gohmert when he identified himself.

"A park service vehicle pulled up as he was putting a note with the ticket on a vacant park service vehicle, so he showed his official card, explained that his congressional plate was showing and he was authorized to park there," she said. "The park service officer said he had not noticed the ... congressional plate in the front window and would not know what it meant had he seen it. The officer accepted the ticket back and apologized."

The police report contains no mention of an apology, according to Politico.

Willingham said Gohmert's office would study the incident and, if he was not allowed to park in the spot, "will most certainly pay the $25 parking ticket."

On Thursday, Citizens for Responsibility and Ethics in Washington, an outside watchdog group, said it filed a complaint with the Office of Congressional Ethics against Gohmert "for conduct that reflects discreditably upon the House."

Source: http://news.yahoo.com/report-rep-gohmert-rude-irate-ticket-185413520.html

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Wednesday, March 27, 2013

Striiv Play


The Striiv Play ($69.95 direct) is an activity tracker that, as its name suggests, is all about making fitness fun. It tracks typical fitness stats like steps taken, stairs climbed, and calories burned, but instead of simply presenting the information in quantifiable terms, it incentivizes the process. There are mini games, personal challenges, and social interaction elements, but the app and device design are missing some of the polish found with competitors like our Editors' Choice, the FitBit One. The Striiv Play will appeal to the younger set, with cartoon avatars and games galore, but those same kid-friendly features will likely turn off serious fitness fanatics.

Design and Setup
A small oblong device, the Striiv Play measures 1.95 by 1.07 by .033 inches (HWD), making it slightly larger than the FitBit One, but still very pocket friendly. Unlike the FitBit, the Striiv Play has a permanently built-in metal clip. That, coupled with the hard lines and edges, makes it less ergonomically friendly, especially if you plan on clipping the device somewhere discreet like a bra strap or waistband. The plastic construction also feels a bit chintzy, while the mirrored plastic face draws attention to the device. There's a button hidden behind one end of the face, which activates the blue OLED readout. Pressing the button scrolls through recorded metrics (steps taken, stairs climbed, miles walked, calories burned, and minutes active), while holding the button brings up the Settings menu. The OLED is bright and clear, making it easy to see exactly where you stand with your daily fitness goals.?

Setup is a bit different than your typical Bluetooth accessory. The Striiv Play uses low-energy Bluetooth 4.0, and the connection must be made through the free iOS app rather than your device's Bluetooth settings menu. The process is easy enough, though, and after following a few prompts, you'll be ready to go. Bluetooth 4.0 also means the Striiv Play is only compatible with the iPhone 4S or later, fifth-gen iPod touches, and the fourth-gen iPad or iPad mini. The Striiv Play automatically syncs with your device when it's in range (about 30 feet). There's no Android support or Web interface like you get with the FitBit.

There's a microUSB port along the side of the Play for charging (a cable is included), and Striiv claims up to 7 days of battery life, but only 3-4 days for active users, on a single charge. In my tests, the Play went from a full charge to half after 3 days of active use.?

Fitness Made Fun
Inline2Like many other activity trackers, the Striiv Play keeps track of stats important to overall fitness. These include steps taken, stairs climbed, miles walked, calories burned, and minutes active. Where the Play differs is how it presents this information and how it challenges you to reach your fitness goals. With the FitBit One, you get a very clean interface with all of your stats in one place. It shows your fitness goals and your current progress, as well as your history over time. This is a boon for proactive users who are already motivated to get active, but there are a few extra features that can help encourage you to do more.

The home page for the app is split into two parts. Swiping to the left or right along along the top half cycles through recorded metrics. Below the current count for each metric is your current challenge with a progress bar showing how close you are to finishing each challenge.

Inline

Striiv utilizes traditional goals and challenges, like reaching a certain number of steps in a day. The challenges also have real world context; for example, a 150-calorie challenge will read "Burn a Soda." Finishing each challenge nets you a virtual trophy, while a more difficult challenge automatically replaces the one you just finished.

Where it gets more interesting is the mini games and social challenges. Striiv encourages you to attain fitness goals with a mini game called MyLand. Imagine a rudimentary city-building game, where you create virtual towns, but instead of using experience or in-game activity, you use real life activity points. The more you move about, the more points you get to use towards improvements for your virtual world. You can also take on quests that net you more points for improvements. Social challenges like relay races let you pit your own activity stats against those of your friends. All of your friends will have to have a Striiv Play as well, though, but it could definitely be a great motivational tool if deployed in a classroom setting. Each player is represented by a virtual avatar (usually an animal), and the race is determined by how much each participant walks and how fast they walk in real life.

Great for Kids, Good for Adults
With the Striiv Play, it's all fun and games, which is great for motivating kids and those who enjoy games to get active. With the childhood obesity problem, I can see the Striiv Play fitting in nicely in a classroom environment, where the games and social challenges will really click with younger kids. But the cartoonish graphics and playful nature might turn off some more serious-minded fitness enthusiasts. And it can't quite match the FitBit One, which lets you do things like log activities and food, as well as track your sleep patterns and even set silent alarms to gently wake you. The Striiv Play is a good activity tracker, and might even be the best for kids, but in terms of overall fitness our Editors' Choice remains with the FitBit One. If your budget is a bit tighter, you should also check out the FitBit Zip, which offers many of the features of its more expensive sibling. And if you prefer the wristband form factor over the clip, be sure to check out the Jawbone UP?or Nike+ Fuelband.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/7O3Vequd7fg/0,2817,2416961,00.asp

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Aye-ayes: Endangered lemurs' complete genomes are sequenced and analyzed for conservation efforts

Mar. 25, 2013 ? For the first time, the complete genomes of three separate populations of aye-ayes -- a type of lemur -- have been sequenced and analyzed in an effort to help guide conservation efforts. The results of the genome-sequence analyses will be published in an early edition of Proceedings of the National Academy of Sciences online during the week of March 25.

The team of scientists is led by George H. Perry, assistant professor of anthropology and biology at Penn State University; Webb Miller, professor of biology and of computer science and engineering at Penn State; and Edward Louis, director of conservation genetics at Omaha's Henry Doorly Zoo and Aquarium and director of the Madagascar Biodiversity Partnership, NGO.

The aye-aye -- a lemur that is found only on the island of Madagascar in the Indian Ocean -- recently was re-classified as "endangered" by the International Union for the Conservation of Nature. "The aye-aye is one of the world's most unusual and fascinating animals," said Perry. "Aye-ayes use continuously growing incisors to gnaw through the bark of dead trees and then a long, thin, and flexible middle finger to extract insect larvae, filling the ecological niche of a woodpecker. Aye-ayes are nocturnal, solitary and have very low population densities, making them difficult to study and sample in the wild."

Perry added that he and other scientists are concerned about the long-term viability of aye-ayes as a species, given the loss and fragmentation of natural forest habitats in Madagascar. "Aye-aye population densities are very low, and individual aye-ayes have huge home-range requirements," said Perry. "As forest patches become smaller, there is a particular risk that there won't be sufficient numbers of individual aye-ayes in a given area to maintain a population over multiple generations. We were looking to make use of new genomic-sequencing technologies to characterize patterns of genetic diversity among some of the surviving aye-aye populations, with an eye towards the prioritization of conservation efforts."

Louis, with his team at Omaha's Henry Doorly Zoo and Aquarium and the Madagascar Biodiversity Partnership, worked to locate aye-ayes and collect DNA samples from three separate regions of Madagascar: the northern, eastern, and western regions. To discover the extent of the genetic diversity in present-day aye-ayes, the researchers generated the complete genome sequences of 12 individual aye-ayes. They then analyzed and compared the genomes of the three populations. They found that, while eastern and western aye-ayes are somewhat genetically distinct, aye-ayes in the northern part of the island and those in the east show a much more significant amount of genetic distance, suggesting an extensive period of time during which interbreeding has not occurred between the populations in these regions.

"Our next step was to compare aye-aye genetic diversity to present-day human genetic diversity," explained Miller. "This analysis can help us to gauge how long the aye-aye populations have been geographically separated and unable to interbreed." To make the comparison, the team gathered 12 complete human DNA sequences -- the same number as the individual aye-aye sequences generated -- from publicly available databases for three distinct human populations: African agriculturalists, individuals of European descent, and Southeast Asian individuals. Using Galaxy -- an open-source, web-based computer platform designed at Penn State for data-intensive biomedical and genetic research -- the team developed software to compare the two species' genetic distances. They found that present-day African and European human populations have a smaller amount of genetic distance than that found to exist between northern and eastern aye-aye populations, suggesting that the aye-aye populations were separated for an especially lengthy period of time by geographic barriers.

"We believe that northern aye-ayes have not been able to interbreed with other populations for some time. Although they are separated by a distance of only about 160 miles, high and extensive plateaus and major rivers may have made intermingling relatively infrequent," explained Miller. He added that the results of the team's data further suggest that the separation of the two aye-aye populations stretches back much longer than 2,300 years, which is when human settlers first arrived on the island and started burning the aye-ayes' forest habitat and hunting lemurs.

The team members hope that their findings will help to guide future conservation efforts for the species. "This work highlights an important region of aye-aye biodiversity in northern Madagascar, and this unique biodiversity is not preserved anywhere except in the wild," said Louis. "There is tremendous historical loss of habitat in northern Madagascar that is continuing at an unsustainable rate today. This study is an excellent example of how a comprehensive and coordinated effort in the field and laboratory can identify previously unknown patterns of biodiversity for an endangered species, which then can be used by conservation organizations to base their management strategies."

The authors added that, in future research, they would like to sequence the genomes of other lemur species -- more than 70 percent of which are considered endangered or critically endangered -- as well as aye-ayes from the southern reaches of the island of Madagascar.

In addition to Perry, Miller, and Louis, other scientists who contributed to this research include Stephan C. Schuster, Aakrosh Ratan, Oscar C. Bedoya-Reina, and Richard Burhans from Penn State; Runhua Lei from the Center for Conservation and Research at Omaha's Henry Doorly Zoo and Aquarium; and Steig E. Johnson from the University of Calgary in Alberta, Canada.

Funding for aye-aye sample collection was provided by Conservation International, the Primate Action Fund, and the Margot Marsh Biodiversity Foundation, along with logistical support from the Ahmanson Foundation and the Theodore F. and Claire M. Hubbard Family Foundation. Additional support comes from the National Institutes of Health, the National Science Foundation, the Pennsylvania Department of Health, and the College of the Liberal Arts at Penn State University.

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The above story is reprinted from materials provided by Penn State. The original article was written by Katrina Voss.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. George H. Perry, Edward E. Louis, Jr., Aakrosh Ratan, Oscar C. Bedoya-Reina, Richard C. Burhans, Runhua Lei, Steig E. Johnson, Stephan C. Schuster, and Webb Miller. Aye-aye population genomic analyses highlight an important center of endemism in northern Madagascar. PNAS, March 25, 2013 DOI: 10.1073/pnas.1211990110

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/th-V7_WkuQM/130325160507.htm

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NLRB sets date for new Kaiser Permanente election ? Business ...

Forty-five thousand Kaiser Permanente employees in California will start receiving new union ballots April 5 following a National Labor Relations Board (NLRB) ruling that a 2010 election was invalid.

The NLRB found that the health workers? union?the Ser??vice Employees International Union-United Healthcare Workers (SEIU-UHW)??interfered with the em??ployees? exercise of a free and reasoned choice? when voting on which union would represent them in 2010. SEIU-UHW won the 2010 election.

The April election is a do-over, pitting the SEIU-UHW against the National Union of Health??care Workers. Kaiser Perma??nente employees will have until April 29 to return their ballots to the company?s Oakland office to allow counting to begin May 1.

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SpaceX Dragon capsule returns from International Space Station

CAPE CANAVERAL, Florida | Tue Mar 26, 2013 3:20pm EDT

CAPE CANAVERAL, Florida (Reuters) - A Space Exploration Technologies' Dragon cargo capsule splashed down in the Pacific Ocean on Tuesday, bringing back science experiments and gear from the International Space Station.

The spacecraft left the orbital outpost at 6:56 a.m. ET, and parachuted into the ocean about 225 miles west of Mexico's Baja California at 12:34 p.m. ET.

"Recovery ship just heard the sonic booms from Dragon re-entry and has data transmission lock," Elon Musk, founder and chief executive of the privately held company known as SpaceX, wrote on Twitter just before splashdown.

A minute later, recovery ship personnel reported seeing Dragon's parachutes, Musk said.

"Recovery ship has secured Dragon," Musk wrote. "Cargo looks A-OK."

The ship will take the capsule to the Port of Los Angeles, near the company's Hawthorne, California, headquarters, a journey expected to take about 30 hours.

Dragon's return began 252 miles above Earth when astronauts aboard the station used a robotic crane to pluck the capsule from its berthing port and set it into orbit.

SpaceX flight controllers then stepped in and remotely commanded Dragon to fire its steering thrusters and begin the 5.5-hour journey home.

"It looks beautiful from here," station flight engineer Thomas Marshburn radioed to Mission Control in Houston as the capsule flew away.

"Sad to see the Dragon go. Performed her job beautifully, heading back to her lair. Wish her all the best for the splashdown today," Marshburn said.

The Dragon cargo ship reached the station on March 3 with more than 2,300 pounds (1,043 kg) of science equipment, spare parts, food and supplies. It was the second of 12 planned cargo runs for NASA under a $1.6 billion contract. A second freighter, built and operated by Orbital Sciences Corp, is expected to debut this year.

The U.S. space agency hired both firms to fill the gap left by the retirement of its space shuttle fleet in 2011.

Dragon's arrival was delayed a day while SpaceX engineers grappled with a thruster pod problem that had threatened to derail the mission.

"I don't want to go through that again. That was hard-core," Musk said during a keynote speech at the South by Southwest conference in Austin, Texas, earlier this month.

PRECISION RENDEZVOUS

Engineers believe the glitch was caused by a blockage in a pressurization line or a stuck valve. It was cleared and the capsule made a precision rendezvous with the station with no problems. An investigation remains under way, said company spokeswoman Christina Ra.

Dragon returned to Earth with 2,668 (1,210 kg) of cargo, including a freezer filled with biological samples from the crew for medical research.

While Russian, European and Japanese freighters also service the station, only the SpaceX vessel is designed to return cargo to Earth, a critical transportation link that had been lost with the retirement of the shuttles.

SpaceX is working to upgrade the Dragon capsule to fly people as well. A test flight with company astronauts is targeted for 2016.

In addition to enhancing the Dragon capsules, SpaceX is working on an upgraded Falcon 9 rocket. Last week, the rocket's new Merlin engines completed a 28th and final test run, certifying it for flight, Ra said.

The company plans to debut its upgraded Falcon 9 rocket on a science satellite-delivery mission for the Canadian Space Agency in June.

That rocket also will be the first flight from SpaceX's new launch pad at Vandenberg Air Force Base in California. Five previous Falcon 9 flights have launched from Cape Canaveral Air Force Station in Florida.

Dragon's return initially was scheduled for Monday, but it was docked an extra day because of high seas in the Pacific.

Meanwhile, Orbital Sciences Corp, which holds an eight-flight, $1.9 billion NASA contract for station resupply flights, plans to test launch its new Antares rocket as early as April 16 from the commercial Mid-Atlantic Regional Spaceport at NASA's Wallops Flight Facility in Virginia.

Orbital's Cygnus cargo capsule is targeted to make a demonstration run to the space station later in the year.

(Editing by Vicki Allen)

Source: http://feeds.reuters.com/~r/reuters/scienceNews/~3/MVurebyFXUQ/story01.htm

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Tuesday, March 26, 2013

Rebel leader takes Central African capital, dissolves constitution

DAKAR, Senegal (AP) ? A rebel leader whose fighters seized the capital of Central African Republic over the weekend has taken to the airwaves to make his first declaration, announcing he has dissolved the country's constitution and will stay in power for three years, according to excerpts from the broadcast carried on French radio.

Michel Djotodia, one of the leaders of the Seleka rebel coalition, said late Monday that he plans to stay in power until 2016, the length of time left in the term of the president he and his soldiers overthrew.

Ousted President Francois Bozize fled the presidential palace over the weekend, resurfacing Monday in the neighboring nation of Cameroon, where the government issued a statement saying he had sought "temporary exile" on their soil.

The Seleka rebel leader justified his coup d'etat, saying Bozize had veered into dictatorship during his 10 years in power.

"Through us, it was the entire population of Central African Republic that rose up as a single man against the president," Djotodia said, according to Radio France Internationale.

"To this effect, we have decided to guide the destiny of the people of the Central African Republic during this transitional period of three years, in keeping with the spirit of the accords signed in Libreville in January 11, 2013 ... As a result, I have decided that it is, therefore, necessary to dissolve the constitution of Dec. 27, 2004, as well as the parliament and the government," he said.

Meanwhile, French forces protecting Bangui's main airport opened fire on three cars that were speeding toward a security checkpoint, said the French Defense Ministry.

The cars, carrying Indian and Chadian citizens, continued despite warning shots. Two Indian citizens were killed, and the wounded Indian and Chadian passengers were taken for medical care, the defense minister said in the statement Monday.

France is investigating into the shooting, the statement said.

Pillaging, meanwhile, continued in the capital, Bangui, days after the Seleka rebels took the city. The rebels' advance started last week when they pushed past Damara, a town 75 kilometers (47 miles) to the northeast, which had marked the line of control drawn by regional forces in January, following an accord signed in Libreville, the capital of neighboring Gabon.

The rebels broke that accord last week, claiming that Bozize's government had failed to make good on a series of promises, including sending back the South African troops guarding the capital. The South African troops came under an onslaught of fire from the Seleka rebels, who shot and killed 13 South African soldiers over the weekend, in their fight to take the capital.

Seleka is a loose coalition of fighters, many of whom fought in previous rebellions. They joined forces last fall, beginning their advance toward the capital in December.

The developments mirrored a similar rebellion in eastern Congo by the M23 rebels, who took the provincial capital of Goma, pressing the government which then agreed to enter into talks with them. Seleka seemed to be taking a page from the Congolese rebels' playbook as they advanced to less than 100 kilometers (60 miles) from the capital.

The Seleka fighters benefited from the growing dissatisfaction with Bozize, who came to power in 2003, at the helm of a column of a different rebel group which also invaded the capital and toppled the former leader.

Bozize is accused of growing cronyism, and in the last election in 2011, around 20 of Bozize's family members and close associates including former mistresses, won posts in the government, according to Louisa Lombard, a postdoctoral fellow in geography at the University of California, Berkeley.

"There was the sense that governing was being carried out by a tighter and tighter circle of people around Bozize," says Lombard, who has been travelling to Central African Republic for the past 10 years for research.

"And although all sorts of technocratic procedures were in place to make the government more inclusive, it was in fact less and less inclusive. The more technocratic people got sidelined. Those who held positions of power did not have much education, much background in their chosen field. There was a disregard for any kind of merit in governing."

Lombard cautions, however, that the Seleka coalition is very loosely held together. Already on Monday, a different rebel leader, 26-year-old Nelson N'Djadder who is based in Paris, said that he does not recognize Djotodia as their new president.

"Seleka is a very heterogeneous group. That is something we noticed since the beginning, when it first emerged," said Lombard. "Holding it together will be a big problem."

___

Lori Hinnant contributed to this report from Paris.

___

Rukmini Callimachi can be reached at www.twitter.com/rcallimachi

Source: http://news.yahoo.com/rebel-leader-dissolves-c-african-constitution-104121961.html

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Lil Wayne's Road To I Am Not A Human Being II

While he insisted the project was 'not important' in 2011, all eyes are on Weezy on the eve of the LP's release.
By Rob Markman


Lil Wayne
Photo: Hutton Supancic/ Getty Images

Source: http://www.mtv.com/news/articles/1704310/lil-waynei-am-not-human-being-ii.jhtml

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Developing our sense of smell

Mar. 25, 2013 ? When our noses pick up a scent, whether the aroma of a sweet rose or the sweat of a stranger at the gym, two types of sensory neurons are at work in sensing that odor or pheromone. These sensory neurons are particularly interesting because they are the only neurons in our bodies that regenerate throughout adult life -- as some of our olfactory neurons die, they are soon replaced by newborns. Just where those neurons come from in the first place has long perplexed developmental biologists.

Previous hypotheses about the origin of these olfactory nerve cells have given credit to embryonic cells that develop into skin or the central nervous system, where ear and eye sensory neurons, respectively, are thought to originate. But biologists at the California Institute of Technology (Caltech) have now found that neural-crest stem cells -- multipotent, migratory cells unique to vertebrates that give rise to many structures in the body such as facial bones and smooth muscle -- also play a key role in building olfactory sensory neurons in the nose.

"Olfactory neurons have long been thought to be solely derived from a thickened portion of the ectoderm; our results directly refute that concept," says Marianne Bronner, the Albert Billings Ruddock Professor of Biology at Caltech and corresponding author of a paper published in the journal eLIFE on March 19 that outlines the findings.

The two main types of sensory neurons in the olfactory system are ciliated neurons, which detect volatile scents, and microvillous neurons, which usually sense pheromones. Both of these types are found in the tissue lining the inside of the nasal cavity and transmit sensory information to the central nervous system for processing.

In the new study, the researchers showed that during embryonic development, neural-crest stem cells differentiate into the microvillous neurons, which had long been assumed to arise from the same source as the odor-sensing ciliated neurons. Moreover, they demonstrated that different factors are necessary for the development of these two types of neurons. By eliminating a gene called Sox10, they were able to show that formation of microvillous neurons is blocked whereas ciliated neurons are unaffected.

They made this discovery by studying the development of the olfactory system in zebrafish -- a useful model organism for developmental biology studies due to the optical clarity of the free-swimming embryo. Understanding the origins of olfactory neurons and the process of neuron formation is important for developing therapeutic applications for conditions like anosmia, or the inability to smell, says Bronner.

"A key question in developmental biology -- the extent of neural-crest stem cell contribution to the olfactory system -- has been addressed in our paper by multiple lines of experimentation," says Ankur Saxena, a postdoctoral scholar in Bronner's laboratory and lead author of the study. "Olfactory neurons are unique in their renewal capacity across species, so by learning how they form, we may gain insights into how neurons in general can be induced to differentiate or regenerate. That knowledge, in turn, may provide new avenues for pursuing treatment of neurological disorders or injury in humans."

Next, the researchers will examine what other genes, in addition to Sox10, play a role in the process by which neural-crest stem cells differentiate into microvillous neurons. They also plan to look at whether or not neural-crest cells give rise to new microvillous neurons during olfactory regeneration that happens after the embryonic stage of development.

Funding for the research outlined in the eLIFE paper, "Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish," was provided by the National Institutes of Health and the Gordon Ross Postdoctoral Fellowship. Brian N. Peng, a former undergraduate student (BS '12) at Caltech, also contributed to the study.

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The above story is reprinted from materials provided by California Institute of Technology. The original article was written by Katie Neith.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. A. Saxena, B. N. Peng, M. E. Bronner. Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish. eLife, 2013; 2 (0): e00336 DOI: 10.7554/eLife.00336

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/XlWN2zcabwc/130325160625.htm

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Neighbors thrilled by N.J. man's $338M Powerball win

PASSAIC, N.J. (AP) ? Pedro Quezada's neighbors see a lot of themselves in the winner of the $338 million Powerball jackpot: hardworking, a family man, an immigrant, and someone who has known hard times.

That's why they're so thrilled that one of their own has finally struck it rich.

Quezada, 44, entered Eagle Liquors store, where his ticket was sold, late Monday afternoon. The Passaic store's owner ran Quezada's ticket through the lottery machine and, as a newspaper and television outlets recorded the moment, validated that it was a winner.

"This is super for all of us on this block," said Eladia Vazquez, who has lived across the street from Quezada's building for the past 25 years. Quezada and his family "deserve it because they are hardworking people."

Quezada told reporters in Spanish that he was "very happy" and that he intends to help his family.

"I still can't believe it," his wife, Ines Sanchez, told The Record in Bergen County. "We never expected it, but thank God."

The New Jersey Lottery confirmed that the winning ticket was validated at Eagle Liquors at 4:30 p.m. Monday, but officials said they didn't yet know the winner's name.

The numbers drawn Saturday were 17, 29, 31, 52, 53 and Powerball 31. A lump sum payout would be $221 million, or about $152 million after taxes. It's the fourth-largest jackpot in Powerball history.

The Quezada family's apartment sits at the end of a short dead end block that abuts a highway in Passaic, 15 miles northwest of New York City.

The block has a half-dozen three-story brick apartment buildings on each side, and Vazquez says it's a neighborhood where everyone knows everyone, including what car they drive and what parking space they use.

Alberto Liranzo, who lives two floors below Quezada, said the lottery winner has five children and owns a bodega in Passaic.

Dominican immigrant Jose Gonzalez said he barbecues and plays dominoes with Quezada in the summers in a backyard on their street.

"He sometimes would work from six in the morning to 11 at night, so I did not see him much," Gonzalez said in Spanish Monday night. "I am happy for him. ... I don't know where he is now but I imagine he will drop by to say hi to his friends."

Neighbors told The Record that the Quezada family has suffered bad luck in recent years. Two years, ago, thieves broke into their apartment and stole everything from clothing to jewelry. The year before, a fire destroyed much of their bodega, they said.

Now, the family's luck has changed with their Powerball success.

"It's a blessing for the neighborhood," resident Daphne Robinson told The Record. "It gives people hope that there is a blessing somewhere, for somebody."

Richard Delgado, who lives down the block from Quezada's building, also described Quezada as "a hard worker, like all of us here. We all get up in the morning and go to work."

Delgado said he got up Sunday morning and was going to take his dog for a walk when he heard the radio announce the Powerball results.

"When I heard there was one winner and it was in New Jersey, I immediately went and checked my tickets," Delgado said. "I wanted to be that guy."

When asked what it would be like to suddenly win such a large amount, Delgado said a person would have to set priorities.

"No. 1 is your health, because if you don't have that, the rest doesn't matter," he said. "No. 2 is your family. You take care of your own and live the rest of your life in peace. That's all anyone can do."

No one had won the Powerball jackpot since early February, when Dave Honeywell in Virginia bought the winning ticket and elected a cash lump sum for his $217 million jackpot.

The largest Powerball jackpot ever came in at $587.5 million in November. The winning numbers were picked on two different tickets ? one by a couple in Missouri and the other by an Arizona man ? and the jackpot was split.

Nebraska still holds the record for the largest Powerball jackpot won on a single ticket ? $365 million ? by eight workers at a Lincoln meatpacking plant in February 2006.

Powerball is played in 42 states, Washington, D.C., and the U.S. Virgin Islands. The chance of matching all five numbers and the Powerball number is about 1 in 175 million.

___

Associated Press writers Claudia Torrens in Passaic and Angela Delli Santi in Lawrenceville, N.J., contributed to this report.

Source: http://news.yahoo.com/neighbors-thrilled-nj-mans-338m-powerball-win-063218162.html

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Sunday, March 24, 2013

Engadget Mobile Podcast 174 - 03.22.13

Engadget Mobile Podcast 174 - 03.22.13

It's not what you do, it's how you do it. Or, at least that's the sentiment this week. Samsung's Galaxy S 4 is raising eyebrows with the mobile crew, and not entirely in the good way. There are musings on the future of Chrome and Android, plus (an attempted) discussion on Sony's latest mobile offerings. You know the drill.

Hosts: Myriam Joire (tnkgrl), Brad Molen

Guest: Joseph Volpe

Producer: James Trew

Music: Tycho - Coastal Brake (Ghostly International)

Hear the podcast

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/U8JUcc3WtxU/

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Samsung exec says former Android chief Andy Rubin was stubborn

By Simon Evans DENVER, Colorado, March 23 (Reuters) - Furious Costa Rica coach Jorge Luis Pinto said it was an "embarassment to football" that Friday's World Cup qualifier with the United States was played in strong snow, while his federation promised to make an official protest. The U.S. won 1-0 but Pinto was riled the game was played on a snowy field with a covering that became deeper as the game wore on. "It was an embarrassment to football, disrespectful to the game," an animated Pinto told reporters. ...

Source: http://news.yahoo.com/samsung-exec-says-former-android-chief-andy-rubin-211115526.html

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RISE:2013 highlights: Kinect rehab, Lego lobsters, 3D printed tech and more

RISE2013 hightlights Kinect rehab, Lego lobsters, 3D printed embedded tech and more

We were excited and honored when the administration at Northeastern University asked us to help judge its RISE:2013 Research, Innovation and Scholarship Expo. The event, held at the physical education center on the school's Boston campus, brings together an incredibly diverse array of research projects covering a impressive number of fields, including physical and life sciences, engineering, humanities, arts & design, computer and information sciences, health sciences, law, business and social sciences.

As you might imagine, scoring works across such a diverse array of concentrations is no easy task. We did, however, manage to pull out a handful of projects that will no doubt be of particular interest to our own readership. The list includes the use of a Kinect camera and PC for physical rehabilitation, the 3D printing of embedded electrical technologies, a Lego set that helps bridge the gap between crustacean and robot and a device that employs an Arduino board and video games to help stroke victims recover motor skills. Check out a video of all of the above just after the break.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/nYir2wU6ME4/

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Saturday, March 23, 2013

Broadway hit 'The Book of Mormon' lands in London

(AP) ? Broadway sensation "The Book of Mormon" has landed in London, to a warm reception from theatergoers and mixed notices from critics

Reviewers delivered their verdicts on the show Friday, after an opening night that counted celebrities including "Homeland" star Damian Lewis and Duran Duran singer Simon Le Bon among the audience.

The exuberantly profane show by "South Park" creators Trey Parker and Matt Stone and "Avenue Q" composer Robert Lopez tells the story of two Mormon missionaries sent to spread the word in Uganda.

Most critics praised the production's skill and energy, though the Daily Telegraph's Charles Spencer said "its mixture of satire and syrup ultimately proves repellent."

Daily Mail critic Quentin Letts was even less enthusiastic: "I tired of it after 10 minutes."

And the Guardian's Michael Billington judged it "mildly amusing. ... a safe, conservative show for middle America."

Reviewers were full of praise for stars Gavin Creel and Jared Gertner as the young missionaries Elder Price and Elder Cunningham. Libby Purves in The Times loved the "big belting numbers, witty lyrics and joyfully athletic dances," but was troubled by the show's message.

She said the musical, "beneath its jollity, is morally null and ? without seeming to notice it ? racist."

"I don't see any Ugandans wanting to" see it, she said. "Even though the dances are great."

The Independent's Paul Taylor was more positive, saying: "I absolutely loved it ? albeit slightly guiltily."

Several critics compared the show unfavorably to "Jerry Springer: the Opera," a British musical that drew angry protests from some Christians.

Far from picketing "The Book of Mormon," the Church of Jesus Christ of Latter-day Saints took out three pages of ads in the program, telling audience members: "You've seen the play ... now read the book."

"The Book of Mormon" won nine Tony Awards in 2011, including best musical, and is a hot ticket in London, where it is sold out through July at the Prince of Wales Theatre.

Among audience members at one preview performance was Prime Minister David Cameron, who was seen laughing heartily throughout.

Stone was impressed the prime minister had attended.

"That would not happen in America," he said. "A politician just wouldn't come to ... they just wouldn't be seen near our (stuff). No way. If you want to get elected, you don't go near Matt and Trey."

___

Associated Press writer Hilary Fox contributed to this report.

___

Online:

Jill Lawless can be reached at http://Twitter.com/JillLawless

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-03-22-Britain-Book%20of%20Mormon/id-cf545900431c4d06b235daf03d3204a3

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Ask A VC: Comcast Ventures' Michael Yang On What's Next In Digital Healthcare And More

michael_yang-large-1In this week's Ask A VC, Comcast Ventures' Managing Director Michael Yang sat in the hot seat to talk about his passion for digital healthcare, and much more.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/sS73aen6gbU/

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Chicago notifies teachers and parents of school closings

CHICAGO (AP) ? The city of Chicago has begun informing teachers, principals and local officials about which public schools it intends to close under a contentious plan that opponents say will disproportionately affect minority students in the nation's third largest school district, teachers said Thursday.

Chicago Public Schools hasn't said how many schools or students will be affected, but administrators identified up to 129 schools that could be shuttered, although the total number is expected to fall short of that number. The district says many of those schools don't serve enough students to justify remaining open, and that the closures will help it deal with a $1 billion budget shortfall and better allocate its resources to students.

The pending closures have been the subject of highly charged community meetings all over the city. Critics say that, among other things, the closures will threaten the safety of students who may have to cross gang boundaries if their schools are closed and that they will cause major inconveniences for families.

Chicago is among several major U.S. cities, including Philadelphia, Washington and Detroit, among others, to use mass school closures to reduce costs and offset declining enrollment.

The issue has led to yet another clash between Mayor Rahm Emanuel and the Chicago Teachers Union over the direction of the city's schools. A strike by the union's 26,000 teachers last fall idled roughly 350,000 students for seven days, and Emanuel has clashed with the union over his push to lengthen the school day.

At Lafayette Elementary, a school in the Humboldt Park neighborhood where 95 percent of its 483 students come from low-income families, the principal read teachers a letter from the district Thursday saying the school is among those it plans to close, said teacher Rosemary Maurello.

Sandra Leon, who was picking up her two grandchildren from kindergarten at Lafayette, wept as she spoke to reporter about the plans, which she heard about from their teacher in a tearful phone call.

"It's been so good for our kids. This school is everything," said Sandra Leon, whose children also attended the school.

The message read to Lafayette teachers said a final decision would be made in May after more community meetings are held and budget plans are reviewed. But Maurello said letters and information packets were already being sent to parents, and the district's message to teachers included a mention of specific plans to move the Lafayette students to another school about 10 blocks away.

"It sounds like a done deal to me," Maurello said.

Like many teachers, she is worried about where her students will end up. As a tenured teacher, the contract allows her to follow her students to their new school, but she wonders if some of them will opt to go to other schools instead.

The district has plans for community organizations to help students get to their new locations safely, but Maurello wonders how long that will last.

"I truly believe that it's going to be chaos," she said.

Many of the schools targeted for possible closure are in parts of south and west Chicago that are beset by gang violence and that have the highest homicide rates, leading to concerns for the safety of students who might have to enter areas farther from home to get to their new schools. Chicago registered more than 500 homicides last year for the first time since 2008.

That violence has hit areas like North Lawndale, where 59-year-old Eular Hatchett walks her 13-year-old nephew, DaVontay Horace, to school to ensure he gets there safely.

"Our parents know about this area," she said. "They don't know about those other areas. If they send him way north or way south, I'm not going to do that. It's too dangerous."

When she dropped her nephew off at Henson Elementary on Thursday, teachers were coming out of a meeting looking distraught and with their heads down, leading her to suspect that it's among those that will close. The teachers told her and others that they weren't permitted to talk about it.

For some of the affected children, it would be the second time in recent years that they've been displaced. When Chicago closed many of its public housing high-rises in recent years, school closings followed.

Many teachers and parents expressed anger and frustration at how the news of the school closures trickled out, leaving some to agonize over rumor and conjecture, instead learning the list of schools in one official announcement.

"In a word, the approach was brutal. It's certainly not deserved by these parents and these kids," said Mary Visconti, the director of the Better Boys Foundation, a youth organization in Lawndale.

A member of the City Council who represents the area, Michael Chandler, told a community gathering that he was informed Wednesday night of two Lawndale schools that will be closing, but he didn't name them.

Chicago Public Schools has until March 31 to announce which of the 129 schools it will close.

After published reports late Wednesday said the announcement would occur Thursday, a CPS spokeswoman said she could not confirm that information. The district released a one paragraph statement from CEO Barbara Byrd-Bennett that reiterated that the announcement would be soon.

"For too long children in certain parts of Chicago have been cheated out of the resources they need to succeed in the classroom because they are in underutilized, under resourced schools," Byrd-Bennett said in the statement.

The district did not respond to requests for comment Thursday.

The list will not be final until the Chicago Board of Education votes on it in late May.

The Chicago Teachers Union, which has vigorously fought the closure plans, did not immediately respond to requests for comment Thursday.

Source: http://news.yahoo.com/chicago-teachers-notice-school-closings-135826568.html

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Thursday, March 21, 2013

Yankees, Red Sox to honor Newtown

(AP) ? The New York Yankees and Boston Red Sox will honor the community of Newtown and the memory of those killed in the shooting at Sandy Hook Elementary School when the teams play opening day April 1 at Yankee Stadium.

Pregame ceremonies include a joint honor guard of Newtown police and firefighters, and a moment of silence at which time a list of the victims' names will be recognized on the center-field scoreboard.

"On opening day, we will reflect upon more important things and the play the game to honor the community of Newtown," Yankees managing general partner Hal Steinbrenner said in a statement. "Since the day of the tragedy, our hearts and thoughts have been with those who were affected."

The Yankees and Red Sox will wear a special ribbon on their uniforms. Baseball commissioner Bud Selig has asked that all other 28 major league teams wear the ribbon during their opening games.

"Months have passed, yet we are still trying to come to grips with this incomprehensible tragedy," Red Sox principal owner John Henry said in a statement. "As our teams look to face each other on opening day, we will stand united in support of the families affected as we remember and honor those who were lost."

Approximately 3,000 people from Newtown will be invited to the ballpark for New York's July 7th game against Baltimore on "Newtown Day at Yankee Stadium."

Associated Press

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Findings to help in design of drugs against virus causing childhood illnesses

Findings to help in design of drugs against virus causing childhood illnesses [ Back to EurekAlert! ] Public release date: 21-Mar-2013
[ | E-mail | Share Share ]

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University

WEST LAFAYETTE, Ind. - New research findings may help scientists design drugs to treat a virus infection that causes potentially fatal brain swelling and paralysis in children.

The virus, called enterovirus 71, causes hand, foot and mouth disease and is common throughout the world. Although that disease usually is not fatal, the virus has been reported to cause fatal encephalitis in infants and young children, primarily in the Asia-Pacific region.

Currently, no cure exists for the infection.

New findings show the precise structure of the virus bound to a molecule that inhibits infection. The findings are detailed in a paper appearing this week in Proceedings of the National Academy of Sciences.

"These results provide a structural basis for development of drugs to fight enterovirus 71 infection," said Michael G. Rossmann, Purdue University's Hanley Distinguished Professor of Biological Sciences.

Rossmann is co-author of a paper with Purdue postdoctoral research associate Pavel Plevka; research scientist Rushika Perera; postdoctoral research associate Moh Lan Yap; Jane Cardosa, a researcher at Sentinext Therapeutics in Malaysia; and Richard J. Kuhn, a professor and head of Purdue's Department of Biological Sciences.

The researchers had previously used a technique called X-ray crystallography to determine the virus's precise structure. A small molecule called a "pocket factor" is located within a pocket of the virus's protective shell, called the capsid. When the virus binds to a human cell, the pocket factor is squeezed out of its pocket resulting in the destabilization of the virus particle, which then disintegrates and releases its genetic material to infect the cell and replicate.

Researchers led by Rossmann have developed antiviral drugs for other enteroviruses such as rhinoviruses that cause the common cold. The drugs work by replacing the pocket factor with a molecule that binds more tightly than the real pocket factor, inhibiting infection. In the new work, the researchers obtained a near-atomic-scale resolution three-dimensional structure of enterovirus 71 binding with an inhibitor called WIN 51711.

"We show that the compound stabilizes the virus and limits its infectivity, probably through restricting dynamics of the capsid necessary for genome release," Rossmann said. "Our results provide a structural basis for development of antienterovirus 71 capsid-binding drugs."

At a resolution of 3.2 angstrom, the images show nearly atomic-scale structural features.

Hand, foot and mouth disease, an infection most common among young children, sometimes arises in a daycare setting. Of the 427,278 cases of the disease recorded in mainland China between January and May 2010, 5,454 cases were classified as severe, with 260 deaths, according to the World Health Organization.

###

The research was supported by the National Institutes of Health and the U.S. Department of Energy.

Writer: Emil Venere, 765-494-4709, venere@purdue.edu

Sources: Pavel Plevka, 765-494-8712, plevka@purdue.edu

Michael Rossmann, 765-494-4911, mr@purdue.edu

Richard J. Kuhn, 765-494-4407, kuhnr@purdue.edu

Rushika Perera, perera@purdue.edu

Related website:

Michael Rossmann: http://www.bio.purdue.edu/molecular_biosciences/directory.php?refID=81

ABSTRACT

Structure of Human Enterovirus 71 in Complex with a Capsid-Binding Inhibitor

Pavel Plevkaa,1, Rushika Pereraa,1, Moh Lan Yapa Jane Cardosab, Richard J. Kuhna, and Michael G. Rossmanna*

aDepartment of Biological Sciences, Purdue University

bSentinext Therapeutics, Malaysia

* To whom correspondence should be addressed: mr@purdue.edu Human enterovirus 71 is a picornavirus causing hand, foot and mouth disease that may progress to fatal encephalitis in infants and small children. As of now, no cure is available for enterovirus 71 infections. Small molecule inhibitors binding into a hydrophobic pocket within capsid viral protein 1 were previously shown to effectively limit infectivity of many picornaviruses. Here we report a 3.2--resolution X-ray structure of the enterovirus 71 virion complexed with the capsid-binding inhibitor WIN 51711. The inhibitor replaced the natural pocket factor within the viral protein 1 pocket without inducing any detectable rearrangements in the structure of the capsid. Furthermore, we show that the compound stabilizes enterovirus 71 virions and limits its infectivity, probably through restricting dynamics of the capsid necessary for genome release. Thus, our results provide a structural basis for development of antienterovirus 71 capsid-binding drugs.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Findings to help in design of drugs against virus causing childhood illnesses [ Back to EurekAlert! ] Public release date: 21-Mar-2013
[ | E-mail | Share Share ]

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University

WEST LAFAYETTE, Ind. - New research findings may help scientists design drugs to treat a virus infection that causes potentially fatal brain swelling and paralysis in children.

The virus, called enterovirus 71, causes hand, foot and mouth disease and is common throughout the world. Although that disease usually is not fatal, the virus has been reported to cause fatal encephalitis in infants and young children, primarily in the Asia-Pacific region.

Currently, no cure exists for the infection.

New findings show the precise structure of the virus bound to a molecule that inhibits infection. The findings are detailed in a paper appearing this week in Proceedings of the National Academy of Sciences.

"These results provide a structural basis for development of drugs to fight enterovirus 71 infection," said Michael G. Rossmann, Purdue University's Hanley Distinguished Professor of Biological Sciences.

Rossmann is co-author of a paper with Purdue postdoctoral research associate Pavel Plevka; research scientist Rushika Perera; postdoctoral research associate Moh Lan Yap; Jane Cardosa, a researcher at Sentinext Therapeutics in Malaysia; and Richard J. Kuhn, a professor and head of Purdue's Department of Biological Sciences.

The researchers had previously used a technique called X-ray crystallography to determine the virus's precise structure. A small molecule called a "pocket factor" is located within a pocket of the virus's protective shell, called the capsid. When the virus binds to a human cell, the pocket factor is squeezed out of its pocket resulting in the destabilization of the virus particle, which then disintegrates and releases its genetic material to infect the cell and replicate.

Researchers led by Rossmann have developed antiviral drugs for other enteroviruses such as rhinoviruses that cause the common cold. The drugs work by replacing the pocket factor with a molecule that binds more tightly than the real pocket factor, inhibiting infection. In the new work, the researchers obtained a near-atomic-scale resolution three-dimensional structure of enterovirus 71 binding with an inhibitor called WIN 51711.

"We show that the compound stabilizes the virus and limits its infectivity, probably through restricting dynamics of the capsid necessary for genome release," Rossmann said. "Our results provide a structural basis for development of antienterovirus 71 capsid-binding drugs."

At a resolution of 3.2 angstrom, the images show nearly atomic-scale structural features.

Hand, foot and mouth disease, an infection most common among young children, sometimes arises in a daycare setting. Of the 427,278 cases of the disease recorded in mainland China between January and May 2010, 5,454 cases were classified as severe, with 260 deaths, according to the World Health Organization.

###

The research was supported by the National Institutes of Health and the U.S. Department of Energy.

Writer: Emil Venere, 765-494-4709, venere@purdue.edu

Sources: Pavel Plevka, 765-494-8712, plevka@purdue.edu

Michael Rossmann, 765-494-4911, mr@purdue.edu

Richard J. Kuhn, 765-494-4407, kuhnr@purdue.edu

Rushika Perera, perera@purdue.edu

Related website:

Michael Rossmann: http://www.bio.purdue.edu/molecular_biosciences/directory.php?refID=81

ABSTRACT

Structure of Human Enterovirus 71 in Complex with a Capsid-Binding Inhibitor

Pavel Plevkaa,1, Rushika Pereraa,1, Moh Lan Yapa Jane Cardosab, Richard J. Kuhna, and Michael G. Rossmanna*

aDepartment of Biological Sciences, Purdue University

bSentinext Therapeutics, Malaysia

* To whom correspondence should be addressed: mr@purdue.edu Human enterovirus 71 is a picornavirus causing hand, foot and mouth disease that may progress to fatal encephalitis in infants and small children. As of now, no cure is available for enterovirus 71 infections. Small molecule inhibitors binding into a hydrophobic pocket within capsid viral protein 1 were previously shown to effectively limit infectivity of many picornaviruses. Here we report a 3.2--resolution X-ray structure of the enterovirus 71 virion complexed with the capsid-binding inhibitor WIN 51711. The inhibitor replaced the natural pocket factor within the viral protein 1 pocket without inducing any detectable rearrangements in the structure of the capsid. Furthermore, we show that the compound stabilizes enterovirus 71 virions and limits its infectivity, probably through restricting dynamics of the capsid necessary for genome release. Thus, our results provide a structural basis for development of antienterovirus 71 capsid-binding drugs.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/pu-fth032113.php

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